Technology Overview

Capsule-in-capsule delivery system and also nano- encapsulation in second layer capsules

This technology facilitates:

• Formulating combination products or dual release of a single ingredient
• Providing multiple release profiles

These capsules can be used for immediate release or combined release—for example solubilized prebiotics in the outer capsule and probiotics in the inner capsule, and the prebiotic gets released immediately and the probiotic would be released later.

The liquid or semi-solid formulation of the outer capsule provides fast liquid release of the ingredient. Lipid-based formulations in either the inner and/or outer capsules may be developed to improve the bioavailability of the formulation.

The company is seeking co-development or JV opportunities with interested companies for this technology.

Technology Features, Specifications and Advantages

Capsule-in-capsule

• This technology can be used for immediate release or combined release.
• The inner capsule of this unique delivery system can contain liquids, semi-solids, powder or pellets.
• The outer capsule can be either a liquid or semi-solid formulation.
• The outer capsule is typically used for immediate release of a combination product, or first phase of a dual release formulation.
• The liquid or semi-solid formulation of the outer capsule provides fast liquid release of the ingredient.
• Lipid-based formulations in either the inner and/or outer capsules may be developed to improve the bioavailability of the formulation.

Nanoencapsulation

• Nanoencapsulation by layer-by-layer techniques
• Nanoencapsulation offers several advantages over microencapsulation. In particular, ultrathin layers should significantly improve mass transport of essential nutrients to the islets and reduce the total volume of material and cells that is transplanted.
• Small size of the capsules does not only allow for transplantation into a vast number of alternative sites within the body, but it can be used for regular CIT.
• Could be used to protect many cell types other than primary islets.

Potential Applications

Liquid-filled hard capsules (LFHC) to help formulate new compounds with improved functionality while providing an elegant and differentiated product presentation. LFHC and lipid-based technology is routinely used for several functional improvements in health & nutritional applications including bioavailability enhancement, taste and odour masking, combination products and delayed release.

Lipid Multi-Particulates (LMP) are an innovation originally developed to enhance the performance of pharmaceutical products. The technology is now available for Consumer Health and Nutrition applications. It can improve the performance of nutritional actives in three distinct categories:

• Modified release
• Taste-masking
• Bioavailability

Customer Benefit

Ideally suited for combination or dual release products – formulating product profiles suitable for health benefit is easier, and consumers are able to get the full benefits from nutrition or medicine.

This single oral dosage delivery system, offers numerous possibilities and a broad range of formulation and design options.

• Formulating combination products or dual release of a single ingredient
• Providing multiple release profiles
• Unique finished product presentation for brand recognition